Understanding Addiction Using Animal Models

Understanding asthma using animal models

Asthma is a complex syndrome with many clinical phenotypes in children and adults. Despite the rapidly increasing prevalence, clinical investigation and epidemiological studies of asthma, the successful introduction of new drugs has been limited due to the different disease phenotypes and ethical issues. Mouse models of asthma replicate many of the features of human asthma, including airway hyp...

Animal models of addiction

In recent years, animal models in psychiatric research have been criticized for their limited translational value to the clinical situation. Failures in clinical trials have thus often been attributed to the lack of predictive power of preclinical animal models. Here, I argue that animal models of voluntary drug intake-under nonoperant and operant conditions-and addiction models based on the Di...

Animal Models of Drug Addiction

Animal Models of Drug Addiction

The study of drug addiction integrates a broad range of research fields including social sciences, psychology, psychiatry, behavioural neurosciences, pharmacology or genetics, each of which being represented in the different chapters of this book. Preclinical studies involving behaving animals have been pivotal for our increasing insights into the psychobiological substrates of addiction and so...

Understanding Through Animal Models

Animal models in biomedical research provide an interactive, dynamic system that can be observed and manipulated experimentally in order to promote our understanding of a human condition or disease by elucidating the biological mechanisms underlying normal function and disease. Animal models allow researchers to test hypotheses about the causes and cures of a disorder and to develop effective t...